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United States: U.S. National Center for Infectious Diseases
Erscheinungsjahr
2023
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Identifying pathogens using traditional culture systems for bacteria and fungi, even when supplemented by use of organism-specific protein or molecular diagnostics, is limited by requiring comparison with known human pathogens stored in datasets. Among the challenges of NGS have been costs (although they have been decreasing), detection of sequences of unknown clinical significance, and gaps in databank records for many viral and other species for comparison with detected sequences, notably among nonhuman species. [...]new zoonotic exposures or recombinant species may be unrecognized or masked by any of numerous unknown nucleic acids. Dr. Fishman is professor of medicine at Harvard Medical School, director of the Transplant Infectious Diseases and Compromised Host Program at Massachusetts General Hospital (MGH), and associate director of the MGH Transplant Center.