Details

Autor(en) / Beteiligte

• Artzi, Ofir
• Cohen, Joel L
• Dover, Jeffrey S
• Suwanchinda, Atchima
• Pavicic, Tatjana
• Landau, Marina
• Goodman, Greg J
• Ghannam, Sahar
• Al Niaimi, Firas
• van Loghem, Jani A J
• Goldie, Kate
• Sattler, Sonja
• Cassuto, Daniel
• Lim, Ting Song
• Wanitphakdeedecha, Rungsima
• Verner, Ines
• Fischer, Tanja C
• Bucay, Vivian
• Sprecher, Eli
• Shalmon, Dana

Titel

Delayed Inflammatory Reactions to Hyaluronic Acid Fillers: A Literature Review and Proposed Treatment Algorithm

Ist Teil von

• Clinical, cosmetic and investigational dermatology, 2020-01, Vol.13, p.371-378

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• There is a wide diversity of opinions regarding the management of delayed inflammatory reactions (DIRs) secondary to hyaluronic acid (HA)-based fillers. The plethora of approaches has led the authors to conduct a review regarding management and treatment of DIRs as well as establish therapeutic guidelines for this purpose. A review of the literature was performed through databases such as PubMed using keywords including HA-fillers and complications, delayed HA filler sequelae and therapy, soft tissue and dermal filler reactions and management. Additionally, a survey comprised of questions regarding the management and treatment of DIRs was sent to 18 physicians highly experienced with soft-tissue filler injections in 10 countries. Their answers and recommendations were analyzed and debated amongst these panelists. Sixteen panelists favored antibiotic therapy as first-line treatment for DIRs, specifically dual antibiotic therapy consisting of a fluoroquinolone along with a tetracycline or macrolide for a period of 3-6 weeks. The majority refrained from the use of intralesional (IL) or systemic steroids except in the case of disfiguring or recalcitrant reactions. IL hyaluronidase was recommended by 13 panelists; however, some preferred a watchful waiting approach for a period of 48 hours to 2 weeks prior to IL hyaluronidase, and in cases where antibiotics did not lead to improvement. A consensus was reached and summarized to propose a clear, easy-to-follow, stepwise algorithm for the treatment of DIRs.