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Chemical Characterization and Biological Properties Assessment of Euphorbia resinifera and Euphorbia officinarum Moroccan Propolis
Ist Teil von
Antibiotics (Basel), 2024-02, Vol.13 (3), p.230
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2024
Quelle
EZB*
Beschreibungen/Notizen
Although the plants of the genus
are largely exploited by therapists in Morocco, the composition and antibacterial activities of propolis from these plants are still unknown. To address this gap, this study aimed to characterize the pollen type, the volatile compounds, and the phenolic and mineral profiles of three
propolis samples collected in Morocco and evaluate their antimicrobial activities. The minimum inhibitory concentration of the propolis samples was determined by the microdilution method, and the anti-adherence activity was evaluated by the crystal violet assay. The examination of anti-quorum-sensing proprieties was performed using the biosensor
CV026. Pollen analysis revealed that
pollen dominated in the P1 sample (58%), while
pollen dominated in the P2 and P3 samples (44%). The volatile compounds were primarily composed of monoterpene hydrocarbons, constituting 35% in P1 and 31% in P2, with α-pinene being the major component in both cases, at 16% in P1 and 15% in P2. Calcium (Ca) was the predominant mineral element in both
(P1) and
(P2 and P3) propolis samples. Higher levels of phenols, flavonoids and dihydroflavonoids were detected in the
P2 sample. The minimum inhibitory concentration (MIC) value ranged from 50 to 450 µL/mL against Gram-positive and Gram-negative bacteria.
propolis displayed the ability to inhibit quorum sensing in the biosensor
CV026 and disrupted bacterial biofilm formation, including that of resistant bacterial pathogens. In summary, the current study evidences the potential use of
propolis (P2 and P3) to combat important features of resistant pathogenic bacteria, such as quorum sensing and biofilm formation.