Details

Autor(en) / Beteiligte

• Choi, Jae‐Il
• Cho, Eun Jeong
• Yang, Min Jae
• Noh, Hyun‐Jin
• Park, So Hyun
• Kim, Seokhwi
• Kim, You‐Sun
• Sung, Chang Ohk
• Lee, Dakeun

Titel

Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer‐associated fibroblasts

Ist Teil von

• Clinical and translational medicine, 2023-10, Vol.13 (10), p.e1438-e1438

Ort / Verlag

Heidelberg: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• To this end, we performed IF on pancreatic cancer tissue and defined iCAFs as IL8-αSMA double-positive spindle-shaped cells. Since the relative αSMA expression in iCAFs is low but still well detected in tissue, we used αSMA to detect both CAF subtypes. [...]we confirmed that the number of iCAFs was significantly increased in distant regions in comparison to the region ≤100 μm from the vessel (Figure 4D), indicating that iCAFs are mainly shaped by the hypoxic TME (Figure 4E). Rather, these are easily explained by ‘hypoxia’ because IL1 can be transcriptionally up-regulated in hypoxic cells7 and HIF1A is a master regulator in establishing iCAF signature as we demonstrated. [...]our concept supports the previously suggested premise that iCAFs and myCAFs can reverse from one cell state to another,3 as hypoxic regions may dynamically change within tumours according to tumour growth and angiogenesis.