Details

Autor(en) / Beteiligte

• Popovici, Corina
• Pavel, Cristina-Maria
• Sunel, Valeriu
• Cheptea, Corina
• Dimitriu, Dan Gheorghe
• Dorohoi, Dana Ortansa
• David, Diana
• Closca, Valentina
• Popa, Marcel

Titel

Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

Ist Teil von

• International journal of molecular sciences, 2021-11, Vol.22 (22), p.12139

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against .