Details

Autor(en) / Beteiligte

• Arimitsu, Nagisa
• Shimizu, Jun
• Fujiwara, Naruyoshi
• Takai, Kenji
• Takada, Erika
• Kono, Takao
• Ueda, Yuji
• Suzuki, Tomoko
• Suzuki, Noboru

Titel

Role of SDF1/CXCR4 interaction in experimental hemiplegic models with neural cell transplantation

Ist Teil von

• International Journal of Molecular Sciences, 2012-03, Vol.13 (3), p.2636-2649

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2012

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models.