Details

Autor(en) / Beteiligte

• Tann, Cally J
• Webb, Emily L
• Lassman, Rachel
• Ssekyewa, Julius
• Sewegaba, Margaret
• Musoke, Margaret
• Burgoine, Kathy
• Hagmann, Cornelia
• Deane-Bowers, Eleanor
• Norman, Kerstin
• Milln, Jack
• Kurinczuk, Jennifer J
• Elliott, Alison M
• Martinez-Biarge, Miriam
• Nakakeeto, Margaret
• Robertson, Nicola J
• Cowan, Frances M

Titel

Early Childhood Outcomes After Neonatal Encephalopathy in Uganda: A Cohort Study

Ist Teil von

• EClinicalMedicine, 2018-12, Vol.6, p.26-35

Ort / Verlag

England: Elsevier

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Neonatal encephalopathy (NE) is a leading cause of global child mortality. Survivor outcomes in low-resource settings are poorly described. We present early childhood outcomes after NE in Uganda. We conducted a prospective cohort study of term-born infants with NE (n = 210) and a comparison group of term non-encephalopathic (non-NE) infants (n = 409), assessing neurodevelopmental impairment (NDI) and growth at 27-30 months. Relationships between early clinical parameters and later outcomes were summarised using risk ratios (RR). Mortality by 27-30 months was 40·3% after NE and 3·8% in non-NE infants. Impairment-free survival occurred in 41·6% after NE and 98·7% of non-NE infants. Amongst NE survivors, 29·3% had NDI including 19·0% with cerebral palsy (CP), commonly bilateral spastic CP (64%); 10·3% had global developmental delay (GDD) without CP. CP was frequently associated with childhood seizures, vision and hearing loss and mortality. NDI was commonly associated with undernutrition (44·1% Z-score < - 2) and microcephaly (32·4% Z-score < - 2). Motor function scores were reduced in NE survivors without CP/GDD compared to non-NE infants (median difference - 8·2 (95% confidence interval; - 13·0, - 3·7)). Neonatal clinical seizures (RR 4.1(2.0-8.7)), abnormalities on cranial ultrasound, (RR 7.0(3.8-16.3), nasogastric feeding at discharge (RR 3·6(2·1-6·1)), and small head circumference at one year (Z-score < - 2, RR 4·9(2·9-5·6)) increased the risk of NDI. In this sub-Saharan African population, death and neurodevelopmental disability after NE were common. CP was associated with sensorineural impairment, malnutrition, seizures and high mortality by 2 years. Early clinical parameters predicted impairment outcomes.