Details

Autor(en) / Beteiligte

• Gimenez-Martins, Ana Paula D’Alarme
• Castanhole-Nunes, Márcia Maria Urbanin
• Nascimento-Filho, Carlos Henrique Viesi do
• Santos, Stéphanie Piacenti dos
• Galbiatti-Dias, Ana Lívia Silva
• Fernandes, Glaucia Maria de Mendonça
• Cuzziol, Caroline Izak
• Francisco, José Luis Esteves
• Pavarino, Érika Cristina
• Goloni-Bertollo, Eny Maria

Titel

Association between folate metabolism polymorphisms and breast cancer: a case-control study

Ist Teil von

• Genetics and molecular biology, 2021-01, Vol.44 (4), p.e20200485-e20200485

Ort / Verlag

Sociedade Brasileira de Genética

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We investigated the association between methylenetetrahydrofolate reductase ( MTHFR C677T and A1298C), methionine synthetase ( MTR A2756G), and methionine synthase reductase ( MTRR A66G) polymorphisms involved in folate pathway and breast cancer risk, and the interaction between these polymorphisms and tobacco and alcohol consumption. Furthermore, we evaluated the association between these polymorphisms and clinicopathological variables. This case-control study included 606 Brazilian women, comprising 128 patients with breast cancer and 478 controls. MTHFR and MTR polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and MTRR polymorphisms using real-time PCR. Age ≥50 years (odds ratio [OR]: 2.65; 95% confidence interval [CI]: 1.65-4.26; p <0.001) and alcohol consumption (OR: 1.76; 95% CI: 1.0-2.85; p =0.021) were associated with an increased risk of breast cancer. For MTHFR A1298C, we observed a reduced risk of developing breast cancer in the codominant model (genotype CC-OR: 0.22; 95% CI: 0.06-0.74; p =0.014), recessive model (OR: 0.22; 95% CI: 0.07-0.76 p =0.004), and log-additive model (OR: 0.70; 95% CI: 0.49-0.98; p =0.035). Women aged ≥50 years and those who are alcohol consumers had increased susceptibility to breast cancer, and MTHFR A1298C modulated the risk for this disease. This is the first study to evaluate the association between polymorphisms in folate metabolism and breast cancer in the northwest region of São Paulo State, Brazil.