Details

Autor(en) / Beteiligte

• Diaz-Marin, Roberto
• Crespo-Garcia, Sergio
• Wilson, Ariel M.
• Buscarlet, Manuel
• Dejda, Agnieszka
• Fournier, Frédérik
• Juneau, Rachel
• Alquier, Thierry
• Sapieha, Przemyslaw

Titel

Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity

Ist Teil von

• Scientific reports, 2021-08, Vol.11 (1), p.15767-15767, Article 15767

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident macrophages, are known to influence adipose tissue homeostasis, relatively little is known about their contribution to BAT function. Here we report that neuropilin-1 (NRP1), a multiligand single-pass transmembrane receptor, is highly expressed in BAT-resident macrophages. During diet-induced obesity (DIO), myeloid-resident NRP1 influences interscapular BAT mass, and consequently vascular morphology, innervation density and ultimately core body temperature during cold exposure. Thus, NRP1-expressing myeloid cells contribute to the BAT homeostasis and potentially its thermogenic function in DIO.