Details

Autor(en) / Beteiligte

• Almeida, Sérgio Monteiro de
• Marquie-Beck, Jennifer
• Bhatt, Archana
• Letendre, Scott
• McCutchan, Allen
• Ellis, Ron

Titel

Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations

Ist Teil von

• Arquivos de neuro-psiquiatria, 2014-07, Vol.72 (7), p.500-505

Ort / Verlag

Brazil: Academia Brasileira de Neurologia - ABNEURO

Erscheinungsjahr

2014

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend portable analyzer were compared to those tested by a reference device (SYNCHRON LX 20). The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.