Details

Autor(en) / Beteiligte

• Belser, Jessica A
• Barclay, Wendy
• Barr, Ian
• Fouchier, Ron A M
• Matsuyama, Ryota
• Nishiura, Hiroshi
• Peiris, Malik
• Russell, Charles J
• Subbarao, Kanta
• Zhu, Huachen
• Yen, Hui-Ling

Titel

Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments

Ist Teil von

• Emerging infectious diseases, 2018-06, Vol.24 (6), p.965-971

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices. We also discuss current limitations of the ferret transmission model and highlight continued refinements and advances to this model ongoing in laboratories. Understanding, disclosing, and standardizing the critical parameters of ferret transmission studies will improve the comparability and reproducibility of pandemic influenza risk assessment and increase the statistical power and, perhaps, accuracy of this model.