Details

Autor(en) / Beteiligte

• Horváth, Balázs
• Szentandrássy, Norbert
• Almássy, János
• Dienes, Csaba
• Kovács, Zsigmond Máté
• Nánási, Péter P
• Banyasz, Tamas

Titel

Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?

Ist Teil von

• Pharmaceuticals (Basel, Switzerland), 2022-02, Vol.15 (2), p.231

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Late sodium current has long been linked to dysrhythmia and contractile malfunction in the heart. Despite the increasing body of accumulating information on the subject, our understanding of its role in normal or pathologic states is not complete. Even though the role of late sodium current in shaping action potential under physiologic circumstances is debated, it's unquestioned role in arrhythmogenesis keeps it in the focus of research. Transgenic mouse models and isoform-specific pharmacological tools have proved useful in understanding the mechanism of late sodium current in health and disease. This review will outline the mechanism and function of cardiac late sodium current with special focus on the recent advances of the area.