Emerging infectious diseases, 2009-08, Vol.15 (8), p.1260-1264
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Increase in pneumococcus macrolide resistance, United States
- Ist Teil von
- Emerging infectious diseases, 2009-08, Vol.15 (8), p.1260-1264
- Ort / Verlag
- United States: U.S. National Center for Infectious Diseases
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- During year 6 (2005-2006) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin surveillance study, 6,747 Streptococcus pneumoniae isolates were collected at 119 centers. The susceptibility of these isolates to macrolides was compared with data from previous years. Macrolide resistance increased significantly in year 6 (35.3%) from the stable rate of approximately 30% for the previous 3 years (p<0.0001). Macrolide resistance increased in all regions of the United States and for all patient age groups. Rates were highest in the south and for children 0-2 years of age. Lower-level efflux [mef(A)]-mediated macrolide resistance decreased in prevalence to approximately 50%, and highly resistant [erm(B) + mef(A)] strains increased to 25%. Telithromycin and levofloxacin susceptibility rates were >99% and >98%, respectively, irrespective of genotype. Pneumococcal macrolide resistance in the United States showed its first significant increase since 2000. High-level macrolide resistance is also increasing.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1080-6040eISSN: 1080-6059DOI: 10.3201/eid1508.081187Titel-ID: cdi_doaj_primary_oai_doaj_org_article_0290d86e8e8f40ea905aa8353f5ff803
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Bacterial pneumonia, Bacterial Proteins - genetics, Child, Child, Preschool, Communicable Diseases, Emerging - drug therapy, Communicable Diseases, Emerging - epidemiology, Communicable Diseases, Emerging - microbiology, Community-Acquired Infections - drug therapy, Community-Acquired Infections - epidemiology, Community-Acquired Infections - microbiology, Drug resistance in microorganisms, Drug Resistance, Bacterial - genetics, Drug therapy, Genotype, Health aspects, Humans, Infant, Infant, Newborn, Macrolide antibiotics, macrolides, Macrolides - pharmacology, Membrane Proteins - genetics, Methods, Methyltransferases - genetics, Middle Aged, Pneumococcal Infections - drug therapy, Pneumococcal Infections - epidemiology, Pneumococcal Infections - microbiology, Pneumonia, Prevalence studies (Epidemiology), PROTEKT US, respiratory infections, Respiratory Tract Infections - drug therapy, Respiratory Tract Infections - epidemiology, Respiratory Tract Infections - microbiology, Risk factors, streptococci, Streptococcus, Streptococcus pneumoniae, Streptococcus pneumoniae - drug effects, Streptococcus pneumoniae - genetics, Streptococcus pneumoniae - isolation & purification, surveillance, Time Factors, United States - epidemiology, Young Adult