International journal of molecular sciences, 2021-01, Vol.22 (3), p.1201
2021
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- Autor(en) / Beteiligte
- Titel
- Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair
- Ist Teil von
- International journal of molecular sciences, 2021-01, Vol.22 (3), p.1201
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms22031201Titel-ID: cdi_doaj_primary_oai_doaj_org_article_022b161c9b9143139b2da2963bacb949
- Format
- –
- Schlagworte
- Animals, Apoptosis, Bone marrow, Cardiac function, Cardiomyocytes, Cell differentiation, Cell therapy, Cell- and Tissue-Based Therapy - adverse effects, Cell- and Tissue-Based Therapy - methods, Clinical Trials as Topic, Cytokines, Disease Models, Animal, Genotype & phenotype, Growth factors, Heart, Heart attacks, Heart Diseases - diagnosis, Heart Diseases - etiology, Heart Diseases - therapy, Heart failure, Humans, Immune response, Immunomodulation, Inflammation, Lymphocytes, mesenchymal stem cells, Mesenchymal Stem Cells - cytology, Mesenchymal Stem Cells - metabolism, Mesenchyme, Molecular modelling, Mortality, Myoblasts, Cardiac - cytology, Myoblasts, Cardiac - metabolism, Myocardial infarction, Neutrophils, Regeneration, Review, stem cell therapy, Stem Cell Transplantation - methods, Stem cells, Stem Cells - cytology, Stem Cells - metabolism, Tissue engineering, Treatment Outcome, Wound Healing