International journal of molecular sciences, 2022-01, Vol.23 (3), p.1353
2022
Details
- Autor(en) / Beteiligte
- Titel
- Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma
- Ist Teil von
- International journal of molecular sciences, 2022-01, Vol.23 (3), p.1353
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments, including surgery, chemotherapy, and radiation, are palliative at best. The design of effective and targeted chemotherapeutic strategies for the treatment of GBM require a thorough analysis of specific signaling pathways to identify those serving as drivers of GBM progression and invasion. The Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways are key regulators of important biological functions that include cell proliferation, epithelial-mesenchymal transition (EMT), metabolism, and angiogenesis. Targeting specific regulatory components of the Wnt/β-catenin and PAM pathways has the potential to disrupt critical brain tumor cell functions to achieve critical advancements in alternative GBM treatment strategies to enhance the survival rate of GBM patients. In this review, we emphasize the importance of the Wnt/β-catenin and PAM pathways for GBM invasion into brain tissue and explore their potential as therapeutic targets.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms23031353Titel-ID: cdi_doaj_primary_oai_doaj_org_article_0202003b79974d13b99a19c191b4bef8
- Format
- –
- Schlagworte
- 1-Phosphatidylinositol 3-kinase, AKT protein, Angiogenesis, Apoptosis, Apoptosis - genetics, Autophagy, beta Catenin - metabolism, Brain cancer, Brain Neoplasms - pathology, Brain tumors, Cancer therapies, Cell adhesion & migration, Cell division, Cell growth, Cell Line, Tumor, Cell Movement - genetics, Cell proliferation, Cell Proliferation - genetics, Chemotherapy, Epithelial-Mesenchymal Transition - physiology, Fatty acids, GBM survival, Gene Expression - genetics, Gene Expression Regulation, Neoplastic - genetics, Genotype & phenotype, Glioblastoma, Glioblastoma - metabolism, Glioblastoma - physiopathology, Glucose, Growth factors, Humans, Kinases, Localization, Mesenchyme, Metastasis, Motility, Mutation, Phosphatidylinositol 3-Kinase - metabolism, Phosphatidylinositol 3-Kinases - metabolism, Phosphorylation, PI3K/Akt/mTOR, Proteins, Proto-Oncogene Proteins c-akt - metabolism, Review, Signal transduction, Signal Transduction - physiology, Signaling, Stem cells, Survival, Therapeutic applications, Therapeutic targets, TOR protein, TOR Serine-Threonine Kinases - metabolism, Tumors, Wnt protein, Wnt Signaling Pathway - physiology, Wnt/β-catenin, β-Catenin