Details

Autor(en) / Beteiligte

• Fish, Ari M.
• Nadig, Ajay
• Seidlitz, Jakob
• Reardon, Paul K.
• Mankiw, Catherine
• McDermott, Cassidy L.
• Blumenthal, Jonathan D.
• Clasen, Liv S.
• Lalonde, Francois
• Lerch, Jason P.
• Chakravarty, M. Mallar
• Shinohara, Russell T.
• Raznahan, Armin

Titel

Sex-biased trajectories of amygdalo-hippocampal morphology change over human development

Ist Teil von

• NeuroImage (Orlando, Fla.), 2020-01, Vol.204, p.116122-116122, Article 116122

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The amygdala and hippocampus are two adjacent allocortical structures implicated in sex-biased and developmentally-emergent psychopathology. However, the spatiotemporal dynamics of amygdalo-hippocampal development remain poorly understood in healthy humans. The current study defined trajectories of volume and shape change for the amygdala and hippocampus by applying a multi-atlas segmentation pipeline (MAGeT-Brain) and semi-parametric mixed-effects spline modeling to 1,529 longitudinally-acquired structural MRI brain scans from a large, single-center cohort of 792 youth (403 males, 389 females) between the ages of 5 and 25 years old. We found that amygdala and hippocampus volumes both follow curvilinear and sexually dimorphic growth trajectories. These sex-biases were particularly striking in the amygdala: males showed a significantly later and slower adolescent deceleration in volume expansion (at age 20 years) than females (age 13 years). Shape analysis localized significant hot-spots of sex-biased anatomical development in sub-regional territories overlying rostral and caudal extremes of the CA1/2 in the hippocampus, and the centromedial nuclear group of the amygdala. In both sexes, principal components analysis revealed close integration of amygdala and hippocampus shape change along two main topographically-organized axes – low vs. high areal expansion, and early vs. late growth deceleration. These results (i) bring greater resolution to our spatiotemporal understanding of amygdalo-hippocampal development in healthy males and females, and (ii) uncover focal sex-differences in the structural maturation of the brain components that may contribute to differences in behavior and psychopathology that emerge during adolescence. •Large-scale longitudinal single center study of volume and shape development for amygdala and hippocampus between childhood and early adulthood.•Sex-differences in trajectories of anatomical maturation with delayed deceleration of amygdala growth in males relative to females.•Localization of sex-differences in regional anatomical maturation within amygdala and hippocampus.•Discovery of two principle spatio-temporal components of coordinated shape change across the amygdala and hippocampus in both sexes.