International journal of molecular sciences, 2020-08, Vol.21 (16), p.5911
2020
Details
- Autor(en) / Beteiligte
- Titel
- R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
- Ist Teil von
- International journal of molecular sciences, 2020-08, Vol.21 (16), p.5911
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Open access e-journals list
- Beschreibungen/Notizen
- Myelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mechanisms can cause neurodegenerative myelin-associated pathologies. From oligodendrocyte progenitor cells to mature myelinating oligodendrocytes, myelination is a highly complex process that involves many elements of cellular signaling, yet many of the mechanisms that coordinate it, remain unknown. In this review, we will focus on the three major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin) and recent advances describing the crosstalk elements which help to regulate them. In addition, we will review the tight relation between Ras GTPases and myelination processes and discuss its potential as novel elements of crosstalk between the pathways. A better understanding of the crosstalk elements orchestrating myelination mechanisms is essential to identify new potential targets to mitigate neurodegeneration.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21165911Titel-ID: cdi_doaj_primary_oai_doaj_org_article_00cea56909ed4cf1a1154894d64139c0
- Format
- –
- Schlagworte
- 1-Phosphatidylinositol 3-kinase, AKT protein, Animals, Axons, Cells (biology), Central nervous system, Crosstalk, Demyelinating Diseases - metabolism, Disease, ERK1/2-MAPK, Gene expression, Glial stem cells, Growth factors, Humans, Kinases, MAP kinase, MAP Kinase Signaling System, Metabolism, Myelin, Myelin Sheath - metabolism, Myelination, Neurodegeneration, oligodendrocyte, Oligodendrocytes, Phosphatidylinositol 3-Kinases - metabolism, Phosphorylation, PI3K/Akt/mTOR, Progenitor cells, Proteins, ras Proteins - metabolism, Review, Sheaths, Signal transduction, Signaling, Synaptic transmission, Target recognition, TOR protein, TOR Serine-Threonine Kinases - metabolism, Vertebrates, Wnt protein, Wnt Signaling Pathway, Wnt/β-catenin, β-Catenin