Details

Autor(en) / Beteiligte

• Ahmed, Mohamed Ibraheem Mahmoud
• Diepers, Paulina
• Janke, Christian
• Plank, Michael
• Eser, Tabea M
• Rubio-Acero, Raquel
• Fuchs, Anna
• Baranov, Olga
• Castelletti, Noemi
• Kroidl, Inge
• Olbrich, Laura
• Bauer, Bernadette
• Wang, Danni
• Prelog, Martina
• Liese, Johannes G
• Reinkemeyer, Christina
• Hoelscher, Michael
• Steininger, Philipp
• Überla, Klaus
• Wieser, Andreas
• Geldmacher, Christof

Titel

Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections

Ist Teil von

• Frontiers in immunology, 2022-12, Vol.13, p.1026473

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• SARS-CoV-2 vaccine breakthrough infections frequently occurred even before the emergence of Omicron variants. Yet, relatively little is known about the impact of vaccination on SARS-CoV-2-specific T cell and antibody response dynamics upon breakthrough infection. We have therefore studied the dynamics of CD4 and CD8 T cells targeting the vaccine-encoded Spike and the non-encoded Nucleocapsid antigens during breakthrough infections (BTI, n=24) and in unvaccinated control infections (non-BTI, n=30). Subjects with vaccine breakthrough infection had significantly higher CD4 and CD8 T cell responses targeting the vaccine-encoded Spike during the first and third/fourth week after PCR diagnosis compared to non-vaccinated controls, respectively. In contrast, CD4 T cells targeting the non-vaccine encoded Nucleocapsid antigen were of significantly lower magnitude in BTI as compared to non-BTI. Hence, previous vaccination was linked to enhanced T cell responses targeting the vaccine-encoded Spike antigen, while responses against the non-vaccine encoded Nucleocapsid antigen were significantly attenuated.