Details

Autor(en) / Beteiligte

• García-Pagán, Juan Carlos
• Caca, Karel
• Bureau, Christophe
• Laleman, Wim
• Appenrodt, Beate
• Luca, Angelo
• Abraldes, Juan G
• Nevens, Frederik
• Vinel, Jean Pierre
• Mössner, Joachim
• Bosch, Jaime

Titel

Early Use of TIPS in Patients with Cirrhosis and Variceal Bleeding

Ist Teil von

• The New England journal of medicine, 2010-06, Vol.362 (25), p.2370-2379

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• In this randomized trial involving patients with cirrhosis and acute variceal bleeding who were at high risk for treatment failure, control of bleeding was more common and mortality was lower among patients assigned to early treatment with a transjugular intrahepatic portosystemic shunt (TIPS) than among those assigned to standard treatment with rescue TIPS, if needed. In patients with cirrhosis and acute variceal bleeding who were at high risk for treatment failure, control of bleeding was more common and mortality was lower among patients assigned to early treatment with a transjugular intrahepatic portosystemic shunt (TIPS) than among those assigned to standard treatment. Variceal bleeding is a severe complication of portal hypertension and a major cause of death in patients with cirrhosis. Advanced liver failure, failure to control variceal bleeding, early rebleeding, and marked elevations in portal pressure are associated with increased mortality. 1 – 3 Combined treatment with vasoactive drugs, prophylactic antibiotics, and endoscopic techniques is the recommended standard of care for patients with acute variceal bleeding. 4 , 5 However, treatment failure occurs in about 10 to 15% of patients, 6 , 7 who require repeat endoscopic treatments and multiple transfusions. 8 – 10 Treatment with a transjugular intrahepatic portosystemic shunt (TIPS) is highly effective in the control of . . .