Details

Autor(en) / Beteiligte

• Vestbo, Jørgen
• Edwards, Lisa D
• Scanlon, Paul D
• Yates, Julie C
• Agusti, Alvar
• Bakke, Per
• Calverley, Peter M.A
• Celli, Bartolome
• Coxson, Harvey O
• Crim, Courtney
• Lomas, David A
• MacNee, William
• Miller, Bruce E
• Silverman, Edwin K
• Tal-Singer, Ruth
• Wouters, Emiel
• Rennard, Stephen I

Titel

Changes in Forced Expiratory Volume in 1 Second over Time in COPD

Ist Teil von

• The New England journal of medicine, 2011-09, Vol.365 (13), p.1184-1192

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• In patients with chronic obstructive pulmonary disease (COPD), lung function decreases rapidly. Analysis of data from a large observational study of COPD showed that the rate of such loss is highly variable, and current smoking was associated with a rapid loss. Since the seminal studY by Fletcher et al. in the 1970s, 1 , 2 it has been widely accepted that chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in forced expiratory volume in 1 second (FEV 1 ). However, surprisingly few longitudinal studies of patient cohorts have provided detailed data regarding the rate of decline in FEV 1 , 3 – 8 and none of these studies have related changes in FEV 1 to specific subgroups of patients with COPD or to levels of systemic biomarkers. We used data from a large, observational, 3-year study that included detailed assessments of patients . . .