Details

Autor(en) / Beteiligte

• Zahra, Maheen
• Ramay, Saman Rauf
• Nisar, Haseeb
• Munir, Mubbasher
• Javaid, Anum
• Khurram, Muhammad
• Shahid, Samiah
• Nisar, Wardah
• Javed, Komal

Titel

Role of Polymorphisms in MicroRNA-196a2, MicroRNA-499 and MicroRNA-146a for Prostate and Gastric Cancer Risk: An Updated Meta-analysis

Ist Teil von

• TSF Journal of Biology, 2024-05, Vol.2 (1), p.17-34

Erscheinungsjahr

2024

Beschreibungen/Notizen

• Numerous studies have reported the polymorphisms in miR-196a2, miR-499 and miR-146a were associated with different types of cancers. However, the results have been inconsistent and varied. Therefore, we conducted a meta-analysis with the addition of the latest articles to explain the effect of these polymorphisms on Prostate (PCa) and Gastric cancer (GC). A total of 27 articles were recruited after a thorough literature analysis by two independent authors under the PRISMA guidelines in which 7 studies were related to PCa and 20 studies were of GC. We used STATA for performing the meta-analysis. The results from our analysis showed that miR-196a2 rs11614913 polymorphism is associated with PCa in allelic model in Asian population (CvsT: OR=1.207, 95%CI: 1.023-1.425, P=0.026), heterozygous model in Asian population (CvsT: OR=1.264, 95%CI: 1.008-1.585, P=0.042) while miR-499 rs3746444 is associated with PCa in allelic model overall population (AvsC: OR=1.201, 95%CI: 1.039 -1.388, P=0.013) and in Asian subjects (AvsC OR=1.23, 95%CI: 1.030-1.469, P=0.022). The miR-499 rs3746444 is also associated with GC in all four genetic models. Our results concluded that miR-196a2 rs11614913 and miR-499 rs3746444 may be involved in the development of PCa in Asian subjects while miR-499 rs3746444 may be related to GC prognosis