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A 73-year-old man underwent distal gastrectomy followed by Roux-en-Y reconstruction with D2 lymph node resection for gastric cancer, and thereafter received adjuvant S-1 chemotherapy for one year. Three years after gastrectomy, metastasis of the gastric cancer to the transverse colon was found, and transverse colectomy was performed. The pathological diagnosis was colon metastasis of gastric cancer, and S-1 chemotherapy was given for one more year after colectomy. Five years and four months after gastrectomy, swelling and pain developed in the right femoris muscle. CT and MRI showed a tumor of 80×70 mm in size in the right biceps femoris muscle. An incisional biopsy of the right femoris muscle was performed, and pathological findings showed poorly differentiated adenocarcinoma compatible with muscle metastasis of the gastric cancer. Since there was no obvious primary tumor in any other organs, we diagnosed the patient with femoris muscle metastasis from gastric cancer. Colon metastasis from gastric cancer is rare and there are only a few reports of asynchronous metastasis to the skeletal muscle.