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The influence of the intestinal microbiota and its modifications on the well-being of patients with depression
Ist Teil von
Postȩpy higieny i medycyny doświadczalnej, 2020-07, Vol.74, p.314-323
Erscheinungsjahr
2020
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Depression is an increasingly common disease that significantly reduces quality of life. The
number of patients with depression is constantly increasing, especially among younger people.
There are many likely causes of depression related to internal as well as environmental factors.
It is possible that the intestinal microbiota may play an important role in the development
of depressive symptoms. Its diversity is important for the proper development and functioning
of the nervous system, in which an important role is played by the gut brain axis, which is the path-way of communication of intestinal microorganisms with the central nervous
system. Changes in the number and diversity of the intestinal microbiota affect many pathways
potentially related to mood, including hypothalamic-pituitary-adrenal axis, tryptophan
metabolism, as well as the synthesis of neurotransmitters, short-chain fatty acids and brainderived
neurotrophic factor. These changes can also affect the response of the immune system
and inflammatory processes. Therefore, it seems that modulation of the intestinal microbiota
through diet components and probiotic supplementation may be extremely important in
the treatment of depression, also as one of the methods of treating this pharmacotherapyresistant
condition.
This work focuses on the effects of intestinal microbiota and its changes on the well-being of
patients with depression.