Details

Autor(en) / Beteiligte

• Inoue, Sho
• Sakamoto, Yasunari
• Sekino, Yusuke
• Nonaka, Takashi
• Iida, Hiroshi
• Endo, Hiroki
• Koide, Tomoko
• Takahashi, Hirokazu
• Maeda, Shin
• Nakajima, Atsushi
• Gotoh, Eiji
• Inamori, Masahiko

Titel

Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)

Ist Teil von

• The Turkish journal of gastroenterology, 2015-03, Vol.26 (2), p.123-127

Ort / Verlag

Turkey

Erscheinungsjahr

2015

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The aim of this study was to determine the correlation between low-dose ramosetron pre-treatment and gastric emptying using a novel, non-invasive technique for measuring gastric emptying, namely, the continuous real-time 13C breath test (BreathID system: Exalenz Bioscience Ltd., Israel). Twelve healthy male volunteers participated in this randomized two-way crossover study. The subjects fasted overnight and were randomly assigned to receive the test meal (200 kcal per 200 mL) after an hour pre-treatment with 5 µg ramosetron or the test meal alone. Gastric emptying was monitored for 4 hours after administration of the test meal with the 13C-acetic acid breath test performed continuously using the BreathID system. Using Oridion Research Software (β version), T 1/2, T lag, GEC and the regression-estimated constants (β and κ) were calculated. The differences in the parameters measured at two time-points were analyzed using Wilcoxon's signed-rank test. There was a significant difference in the calculated parameter β. No significant differences in the calculated parameters T 1/2, T lag, GEC or κ were observed between the test meal with ramosetron group and the test meal alone group. This study showed that ramosetron pre-treatment enhances the early gastric emptying of liquid nutrients.