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Antitrypanosomal And Haematological Effects Of Selected Nigerian Medicinal Plants In Wistar Rats
Ist Teil von
Biokemistri, 2006-08, Vol.17 (2)
Ort / Verlag
Nigeria: Nigerian Society for Experimental Biology
Erscheinungsjahr
2006
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Studies to determine the effect of some Nigerian Medicinal plants on
some haematological parameters of rats infected with T. b. brucei was
carried out. The plants investigated and the dose levels per kilogram
body weights used are fresh Momordica balsamina pulp (150mg); fresh
Aloe vera pulp (1ml); aqueous extracts of Securidaca longipenduculata
root and root bark (100mg) and Annona senegalensis leaves (200mg).
All the animals were treated orally for seven consecutive days after
establishment of parasitaemia. Parasitaemia and some haematological
parameters were determined before and after treatment as well as
pathochemical composition of each plant. The result showed a
significant (P < 0.05) improvement in Packed Cell Volume (PCV)
values of rats treated with M. balsamina; A. vera and S.
longipenduculata (root bark) when compared with the positive control.
Total leukocyte and lymphocyte counts did not change significantly (P
> 0.05) in groups treated with M. balsamina and S. longipenduculata
(root bark) but increased in other treated and positive control groups.
Similarly, no significant changes (P > 0.05) in neutrophils was
observed in M. balsamina and S. longipenduculata (root) treated animals
but an increase was seen in S. longipenduculata (root bark), A. vera
and infected on treated groups. Treatment with M. balsamina, A. vera
and S. longipenduculata (root and root bark) prolonged the lives of
animals by 4, 1, 3 and 4 days respectively when compared with the
positive control. Differences in the composition of various
phytochemical of these plants could be responsible for the varied
antitrypanosomal activities. Consequently, these plants have great
potential which need to be exploited fully in the management of African
trypanosomiasis.