Autophagy, 2011-04, Vol.7 (4), p.434-435
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Cardioprotection through autophagy: Ready for clinical trial?
- Ist Teil von
- Autophagy, 2011-04, Vol.7 (4), p.434-435
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2011
- Quelle
- Taylor & Francis
- Beschreibungen/Notizen
- Interventions that reduce infarct size in animal models have largely failed to improve outcome in patients suffering acute myocardial infarction (MI), or 'heart attack'. Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1554-8627eISSN: 1554-8635DOI: 10.4161/auto.7.4.14442Titel-ID: cdi_crossref_primary_10_4161_auto_7_4_14442
- Format
- –
- Schlagworte
- Animals, Anti-Infective Agents - pharmacology, Autophagic Punctum, Autophagy, Binding, Biology, Bioscience, Calcium, Cancer, Cell, Chloramphenicol - analogs & derivatives, Chloramphenicol - pharmacology, Clinical Trials as Topic, Comorbidity, Coronary Vessels - pathology, Cycle, Humans, Landes, Myocardial Infarction - metabolism, Myocardial Infarction - pathology, Myocardium - pathology, Organogenesis, Placebos, Proteins, Swine, Time Factors, Treatment Outcome