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Morbidity and treatment costs of cystic fibrosis in a middle-income country
Ist Teil von
Singapore medical journal, 2023-09
Erscheinungsjahr
2023
Link zum Volltext
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
Abstract
Introduction:
Asian children with cystic fibrosis (CF) managed in Malaysia have significant morbidity with limited access to life-sustaining treatments. We determined the morbidity and treatment cost of CF in a resource-limited country.
Methods:
This cross-sectional study included all children diagnosed with CF in our centre. Data on clinical presentation, genetic mutation, serial spirometry results and complications were collected. Out-of-pocket (OOP) and healthcare costs over 1 year were retrieved for patients who were alive. Cohen’s
d
and odds ratio (OR) were used to determine the effect size.
Results:
Twenty-four patients were diagnosed with CF. Five patients died at a median (range) age of 18 (0.3–22) years. F508deletion (c. 1521_1523delCTT) was found in 20% of the alleles, while 89% of the variants were detected in nine patients. Body mass index (BMI) Z score was >−1.96 in 70.6% of patients. Two thirds (68%) were colonised with
Pseudomonas aeruginosa
, and this was associated with lower weight (
P
= 0.009) and BMI (
P
= 0.02) Z scores. Only 18% had FEV
1
Z scores >−1.96. Early symptom onset (
d
= 0.74), delayed diagnosis (
d
= 2.07), a low FEF
25–75
Z score (
d
= 0.82) and a high sweat conductance (
d
= 1.19) were associated with death. Inpatient cost was mainly from diagnostic tests, while medications contributed to half of the outpatient cost. Healthcare utilisation cost was catastrophic, amounting to 20% of the total income.
Conclusion:
Asian children with CF suffer significant complications such as low weight, low lung function and shortened lifespan.
P. aeruginosa
colonisation was frequent and associated with poor growth. Healthcare cost to parents was catastrophic.