Details

Autor(en) / Beteiligte

• Roffler, Steve R
• Li, Ya-Chen
• Chen, Bing-Mae
• Wu, Pei-Chun
• Cheng, Tian-Lu
• Liao, Yuan-Chun
• Kao, Lung-Sen
• Tao, Mi-Hua
• Lieber, Andre

Titel

Physical forces can trigger T cell receptor signaling (35.10)

Ist Teil von

• The Journal of immunology (1950), 2009-04, Vol.182 (1_Supplement), p.35-35.10

Erscheinungsjahr

2009

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• Abstract Engagement of the T cell receptor (TCR) by antigenic peptides presented by the major histocompatibility complex (pMHC) activates specific T cells to control infections. The mechanism of TCR triggering, however, has remained obscure. Here, using micromanipulation of individual T cells, we show that physical forces acting on the TCR can induce calcium mobilization in a Lck-dependent manner. Investigation of artificial antigen-presenting cells (APCs) expressing engineered TCR ligands supports a model in which intercellular tension on the TCR generated during ligand engagement can initiate signaling in T cells. Furthermore, specific interactions between intercellular adhesion molecule-1 (ICAM-1) on APCs and the integrin LFA-1 on T cells may regulate tension to set the threshold for TCR triggering during ligand engagement.