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Cleveland Clinic journal of medicine, 2004-02, Vol.71 (Suppl 2), p.S42-S42
Ort / Verlag
United States: Cleveland Clinic
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
Antiepileptic drugs (AEDs) are associated with bone disease. Early reports found rickets in children and osteomalacia in adults,
but those reports were primarily in institutionalized persons. Studies in ambulatory adults and children taking AEDs do not
reveal rickets or osteomalacia but do report abnormalities in biochemical indexes of bone mineral metabolism and density.
In addition, fracture rates are increased in AED-treated patients. AEDs that induce the cytochrome P450 enzyme system are
most commonly associated with abnormalities in bone. Emerging data suggest that valproate, an enzyme inhibitor, may also affect
bone, and there is limited information on the newer AEDs. Several theories on the mechanism of AED-associated bone disease
have been proposed, but no single one explains all the reported findings. Identifying AED-treated patients who are at risk
for or have bone disease is important, as multiple therapies are available.