Details

Autor(en) / Beteiligte

• Erdelean, Dragos
• Farcas, Simona Sorina
• Poroch, Vladimir
• Andreescu, Nicoleta Ioana
• Erdelean, Izabella
• Dobrescu, Andreea Iulia
• Nussbaum, Laura Alexandra
• Hogea, Lavinia Maria
• Navolan, Dan
• Tutac, Paul
• Puiu, Maria

Titel

Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss

Ist Teil von

• Revista de chimie (Bucuresti), 2018-12, Vol.69 (11), p.3122-3125

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Spontaneous miscarriage is reported in approximately 15% of the clinically recognized pregnancies. Several reports have showed an increased risk of miscarriage in patients with thrombophilia, but due to the heterogeneity of study design the role thrombophilic factors and the use of anticoagulant therapy in prevention of pregnancy loss is still unclear. The current study includes 55 patients for which we ran a screening of the most commonly inherited thrombophilia mutations (FVL, FII, MTHFR C677T/A1298, PAI 4G/5G mutations). We found that most of the patients (92.72%) associated mutation in at least 2 of the genes evaluated. Only a small number of patients (7.27%) had a single variant identified. We have found high prevalence of the studied variants in the pregnant patients that experience pregnancy loss, with risk allele frequencies increased from 2 to 11 times as compared to the general population. We consider that evaluation of the trombophilic variants should be indicated for patients with pregnancy loss in order to establish a possible cause for the miscarriage.