Details

Autor(en) / Beteiligte

• Ali, Taher M
• Elwy, Reem
• Abdelrazik, Bassante
• Soliman, Mohamed A R
• Alsawy, Mohamed F
• Abdullah, Ahmed
• Ahmed, Eman
• Zaki, Shurouk
• Salem, Amany A
• Katri, Mohamed A
• Elhamaky, Mostafa
• Kandel, Haitham
• Marei, Ahmed A
• Menabbawy, Ahmed Al
• Ghoul, Ahmed M F
• Hafez, Ahmed A
• Abdelbar, Sarah
• Moharam, Reham Khaled
• Hany, Ayman
• Hasanin, Ahmed
• Marx, Sascha
• Fleck, Steffen
• Baldauf, Jörg
• Schroeder, Henry W S
• Refaee, Ehab El
• Zohdi, Ahmed

Titel

Risk factors of congenital hydrocephalus: a case-control study in a lower-middle-income country (Egypt)

Ist Teil von

• Journal of neurosurgery. Pediatrics, 2023-05, Vol.31 (5), p.397-9

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Hydrocephalus is the most common brain disorder in children and is more common in low- and middle-income countries. Research output on hydrocephalus remains sparse and of lower quality in low- and middle-income countries compared with high-income countries. Most studies addressing hydrocephalus epidemiology are retrospective registry studies entailing their inherent limitations and biases. This study aimed to investigate child-related, parental, and socioeconomic risk factors of congenital hydrocephalus (CH) in a lower-middle-income country. An investigator-administered questionnaire was used to query parents of patients with CH and controls who visited the authors' institution from 2017 until 2021. Patients with secondary hydrocephalus and children older than 2 years of age at diagnosis were excluded. Uni- and multivariable logistic regression was performed to identify the factors affecting CH development. Seven hundred forty-one respondents (312 cases and 429 controls) were included in this study. The authors showed that maternal diseases during pregnancy (OR 3.12, 95% CI 1.96-5.03), a lack of periconceptional folic acid intake (OR 1.92, 95% CI 1.32-2.81), being a housewife (OR 2.66, 95% CI 1.51-4.87), paternal illiteracy (OR 1.65, 95% CI 1.02-2.69), parental consanguinity (OR 3.67, 95% CI 2.40-5.69), a history of other CNS conditions in the family (OR 2.93, 95% CI 1.24-7.34), conceiving a child via assisted fertilization techniques (OR 3.93, 95% CI 1.57-10.52), and the presence of other congenital anomalies (OR 2.57, 95% CI 1.38-4.87) were associated with an independent higher odds of a child having CH. Conversely, maternal hypertension (OR 0.22, 95% CI 0.09-0.48), older maternal age at delivery (OR 0.93, 95% CI 0.89-0.97), and having more abortions (OR 0.80, 95% CI 0.67-0.95) were negatively correlated with CH. Multiple parental, socioeconomic, and child-related factors were associated with higher odds for developing CH. These results can be utilized to guide parental counseling and management, and direct social education and prevention programs.