Details

Autor(en) / Beteiligte

• Kim, J. Y.
• Park, S. S.
• Jung, H. L.
• Keum, D. H.
• Park, H.
• Chang, Y. H.
• Lee, Y. J.
• Cho, H. I.

Titel

Hb Madrid [β115(G17)Ala→Pro] in a Korean Family with Chronic Hemolytic Anemia

Ist Teil von

• Hemoglobin, 2000-01, Vol.24 (2), p.133-138

Ort / Verlag

England: Informa UK Ltd

Erscheinungsjahr

2000

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Hb Madrid, in which the alanine residue at beta115 (G17) is replaced by proline, results in a moderately severe hemolytic anemia due to the disruption of an alpha helical region and the weakening of an alpha1 beta1 contact (1,2). It was first discovered in a single Spanish patient, by protein structural analysis, whose parents did not carry the abnormality (1). The second observation of Hb Madrid was in an American Black teenager by DNA analysis, who had the family history of chronic hemolytic anemia, but none of family members were available for evaluation (3).