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Salmonella Infection in Total Hip Replacement: Tests to Predict the Outcome of Antimicrobial Therapy
Ist Teil von
Scandinavian journal of infectious diseases, 1990, Vol.22 (5), p.611-618
Ort / Verlag
Basingstoke: Informa UK Ltd
Erscheinungsjahr
1990
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
We report a hematogenous implant infection with Salmonella dublin in a renal transplant patient with total hip replacement. A 16-month treatment with cotrimoxazole foiled, as evidenced by culture and electron microscopy, despite persisting low MIC after therapy. Data from a foreign body animal model and in vitro tests, which take into account the properties of adhering and stationary-phase bacteria, explain the failure of a long-term treatment with cotrimoxazole. The patient was subsequently cured by ciprofloxacin which was successful in these tests. No relapse was noted after a follow-up of 1 year.