Scandinavian journal of gastroenterology, 1986, Vol.21 (S125), p.170-173
1986
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Details
- Autor(en) / Beteiligte
- Titel
- Strategies for Preventing Aspirin-Induced Gastric Bleeding
- Ist Teil von
- Scandinavian journal of gastroenterology, 1986, Vol.21 (S125), p.170-173
- Ort / Verlag
- England: Informa UK Ltd
- Erscheinungsjahr
- 1986
- Quelle
- Taylor & Francis
- Beschreibungen/Notizen
- Prostaglandins protect the gastric mucosa in animals, but the evidence of an effect independent of pH changes in man is not overwhelming. Gastrointestinal bleeding because of non-steroidal anti-inflammatory drugs is a major clinical problem, which we have investigated in a model system measuring bleeding rates caused by short-term administration of aspirin. Of the various strategies tested, only those that elevated intra-gastric pH reduced aspirin-induced bleeding.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-5521, 0085-5928eISSN: 1502-7708DOI: 10.3109/00365528609093834Titel-ID: cdi_crossref_primary_10_3109_00365528609093834
- Format
- –
- Schlagworte
- Acid, Animals, Anti-Inflammatory Agents - pharmacology, Anti-Inflammatory Agents - therapeutic use, aspirin, Aspirin - administration & dosage, Aspirin - adverse effects, Aspirin - analogs & derivatives, bleeding, Cattle, Enprostil, fatty acids, Fatty Acids, Essential, Fatty Acids, Unsaturated - therapeutic use, Female, gamma-Linolenic Acid, Gastrointestinal Hemorrhage - chemically induced, Gastrointestinal Hemorrhage - prevention & control, Humans, Linoleic Acid, Linoleic Acids - therapeutic use, Lysine - administration & dosage, Lysine - analogs & derivatives, Male, Milk, mucosa, Plant Oils, prostaglandins, Prostaglandins E, Synthetic - therapeutic use, protection, Ranitidine - therapeutic use, stomach