Details

Autor(en) / Beteiligte

• Leerhøy, Bonna
• Nordholm-Carstensen, Andreas
• Novovic, Srdan
• Hansen, Mark Berner
• Jørgensen, Lars Nannestad

Titel

Effect of body weight on fixed dose of diclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

Ist Teil von

• Scandinavian journal of gastroenterology, 2016-08, Vol.51 (8), p.1007-1012

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: The aim of this study was to assess the influence of patient body weight on the clinical effect of 100 mg diclofenac administered as a single dose for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). Materials and methods: All patients subjected to endoscopic retrograde cholangiopancreatography (ERCP) from 2009 to 2014 were evaluated for inclusion. In total, 772 patients were included of whom 378 (49%) received diclofenac prophylaxis. Results: In the diclofenac prophylaxis group, body weight was higher in patients with PEP (mean ± SD: 82 ± 18 kg) than in patients without PEP (74 ± 18 kg) (p = 0.029). In patients not receiving prophylaxis, body weight was not associated with the occurrence of PEP (mean ± SD: 77 ± 18 vs 75 ± 18 kg, respectively, p = 0.450). In an adjusted analysis, higher patient body weight was inversely associated with the clinical effect of 100 mg diclofenac for the prophylaxis of PEP. Conclusions: High patient body weight was associated with a reduced effect of 100 mg diclofenac for prophylaxis of PEP.