Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Response Assessment of 68 Ga-DOTA-E-[c(RGDfK)] 2 PET/CT in Lung Adenocarcinoma Patients Treated with Nintedanib Plus Docetaxel
Ist Teil von
Journal of Nuclear Medicine, 2018-03, Vol.59 (3), p.403-409
Ort / Verlag
United States
Erscheinungsjahr
2018
Quelle
The Electronic Journals Library
Beschreibungen/Notizen
Nintedanib is an oral angiokinase inhibitor used as second-line treatment for non-small cell lung cancer. New radiotracers, such as
Ga-DOTA-E-[c(RGDfK)]
, that target α
β
integrin might have an impact as a noninvasive method for assessing angiogenesis inhibitors.
From July 2011 through October 2015, 38 patients received second-line nintedanib plus docetaxel. All patients underwent PET/CT with
Ga-DOTA-E-[c(RGDfK)]
radiotracer and blood-sample tests to quantify angiogenesis factors (fibroblast growth factor, vascular endothelial growth factor, and platelet-derived growth factor AB) before and after completing 2 therapy cycles.
Of the 38 patients, 31 had available baseline and follow-up PET/CT. Baseline lung tumor volume addressed with
Ga-DOTA-E-[c(RGDfK)]
PET/CT correlated with serum vascular endothelial growth factor levels, whereas baseline lung/liver SUV
index correlated with platelet-derived growth factor AB. After treatment, the overall response rate and disease control rate were 7.9% and 47.3%, respectively. A greater decrease in lung tumor volume (-37.2% vs. -27.6%) was associated with a better disease control rate in patients (
= 0.005). Median progression-free survival was 3.7 mo. Nonsmokers and patients with a higher baseline lung tumor volume were more likely to have a higher progression-free survival (6.4 vs. 3.74 [
= 0.023] and 6.4 vs. 2.1 [
= 0.003], respectively). Overall survival was not reached. Patients with a greater decrease in lung SUV
(not reached vs. 7.1 mo;
= 0.016) and a greater decrease in the lung/spleen SUV
index (not reached vs. 7.1;
= 0.043) were more likely to have a longer overall survival.
Ga-DOTA-E-[c(RGDfK)]
PET/CT is a potentially useful tool for assessing responses to angiogenesis inhibitors. Further analysis and novel studies are warranted to identify patients who might benefit from this therapy.