Details

Autor(en) / Beteiligte

• Ohtsubo, Yoshito
• Ohno, Jyunko
• Nishikawa, Makiya
• Fujita, Takuya
• Hashida, Mitsuru
• Sezaki, Hitoshi

Titel

Hepatic targeting of proteins utilizing carbohydrate recognition mechanism

Ist Teil von

• Drug Delivery System, 1991/01/10, Vol.6(1), pp.13-17

Ort / Verlag

THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Erscheinungsjahr

1991

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Effectiveness of a hepatic targeting system utilizing carbohydrate recognition mechanism was evaluated. Three types of bovine serum albumin (BSA)derivatives with 1-thiogalactoside(Gal-BSA), 1-thioglucoside(Glc-BSA), and 1-thiomannoside (Man-BSA) were synthesized by the amidation method and their disposition characteristics in mice were studied. Gal-BSA and Glc-BSA were rapidly taken up by the liver parenchymal cells, while Man-BSA was accumulated in the non-parenchymal cells due to receptor-mediated endocytosis. Similar results were observed in glycosylated superoxide dismutase and carboxymethyldextran, suggesting wide applicability of this methodology.