Details

Autor(en) / Beteiligte

• Alecu, Lucian
• Orlov-Slavu, Cristina
• Tulin, Adrian
• Niţipir, Cornelia

Titel

Trends in systemic therapy for malignant peripheral nerve sheath tumors

Ist Teil von

• Romanian Journal of Orthopaedic Surgery and Traumatology, 2019-12, Vol.2 (2), p.139-142

Ort / Verlag

Sciendo

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Malignant peripheral nerve sheath tumors are a type of soft tissue sarcoma deriving from Schwann cells that usually appear in type 1 neurofibromatosis patients but also sporadically. Tumors frequently interest the nerves in the limbs. They represent a therapeutical challenge due to difficulty of resection and relative radio-resistance and chemo-resistance. The paper aims to describe targeted therapy used in this setting and news concerning the molecular changes that lead to carcinogenesis initiation and promotion. A short selection of literature data was made using PRISMA criteria on this topic. However, due to the rarity and heterogeneity of these tumors, personalized treatment is necessary.