Details

Autor(en) / Beteiligte

• ROY, ANIRBAN
• GROSMAN, BENYAMIN
• PARIKH, NEHA
• WU, DI
• LINTEREUR, LOUIS J.
• KURTZ, NATALIE
• KAUFMAN, FRANCINE R.

Titel

1040-P: Evaluation of a Medtronic Enhanced Hybrid Closed-Loop (e-HCL) System during Unannounced Meals of Medium Size

Ist Teil von

• Diabetes (New York, N.Y.), 2019-06, Vol.68 (Supplement_1)

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background: Forgetting a premeal bolus can lead to hyperglycemia in patients with type 1 diabetes (T1D). A prototype e-HCL system was designed to automatically deliver basal insulin and correction boluses based on sensor glucose (SG) values. The effect of the system on hyperglycemia due to unannounced medium-sized meals was assessed. Methods: Twelve subjects with T1D aged 15-25 years (median 17 years) underwent a 1-week hotel phase of e-HCL Auto Mode use, followed by a 3-week unsupervised at-home phase of use. On the third day of the hotel phase, a ∼40gm-carbohydrate (carb) dinner was consumed without a premeal bolus. Five hours of postprandial data were analyzed and compared to data captured after 40gm-carb meals eaten during the at-home phase, but accompanied by a premeal bolus. Results: Meals without a premeal bolus resulted in postprandial SG levels statistically similar to those observed for meals accompanied by a premeal bolus (Table). Conclusion: These data suggest that e-HCL can handle unannounced medium-sized meals to a similar extent as meals of equal size accompanied by premeal boluses. This may improve overall glycemic control of patients who underestimate or frequently forget to administer premeal boluses. Disclosure A. Roy: Employee; Self; Medtronic MiniMed, Inc. B. Grosman: Employee; Self; Medtronic. N. Parikh: None. D. Wu: None. L.J. Lintereur: Employee; Self; Medtronic MiniMed, Inc. N. Kurtz: Employee; Self; Medtronic MiniMed, Inc. F.R. Kaufman: Employee; Self; Medtronic.