Details

Autor(en) / Beteiligte

• Markovic, D., School of Dentistry, Belgrade (Serbia)
• Zivojinovic, V., School of Dentistry, Belgrade (Serbia)
• Jokanovic, V., Vinca Institute of Nuclear Sciences, Belgrade (Serbia)
• Krstic, V., Faculty of Veterinary Medicine, Belgrade (Serbia)

Titel

Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method

Ist Teil von

• Acta veterinaria (Beograd), 2006, Vol.56 (5-6), p.541-551

Erscheinungsjahr

2006

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Evaluation of biomaterials as safe and effective therapies needs preclinical models to estimate their biologic potential. This paper investigates biocompatibility by the in vivo assessment of the muscle tissue reaction after implantation of the hydrothermaly produced calciumhydroxyapatite. Specific attention has to be given to the synthesis technique which influences the stereology of the material and the behaviour of the material in living tissues. Biocompatibility assessment revealed that only mild to moderate inflammatory reaction was seen around the calciumhydroxyapatite implants. Calciumhydroxyapatite failed to show any substantional toxicity.