Details

Autor(en) / Beteiligte

• Tanaka, Takaaki
• Taoka, Masataka
• Makimoto, Go
• Ninomiya, Kiichiro
• Higo, Hisao
• Fujii, Masanori
• Ichihara, Eiki
• Ohashi, Kadoaki
• Hotta, Katsuyuki
• Tabata, Masahiro
• Maeda, Yoshinobu

Titel

Severe Cytokine Release Syndrome and Immune Effector Cell-associated Neurotoxicity Syndrome in a Man Receiving Immune Checkpoint Inhibitors for Lung Cancer

Ist Teil von

• Internal Medicine, 2024/05/01, Vol.63(9), pp.1261-1267

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• A 55-year-old man with stage IV lung adenocarcinoma was treated with cisplatin, pemetrexed, nivolumab, and ipilimumab. Approximately 100 days after treatment initiation, he became disoriented and presented to the emergency department with a high fever. Blood tests revealed liver and kidney dysfunctions. Subsequently, the patient developed generalized convulsions that required intensive care. He was clinically diagnosed with cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Organ damage was gradually controlled with immunosuppressive drugs, including steroids, and the patient was discharged. Successful treatment is rare in patients with CRS, including ICANS, during immune checkpoint inhibitor treatment for solid tumors.