Details

Autor(en) / Beteiligte

• Hayashi, Daichi
• Nishida, Tsutomu
• Osugi, Naoto
• Kusunoki, Yasuo
• Okabe, Satoru
• Fujii, Yoshifumi
• Nakamatsu, Dai
• Matsumoto, Kengo
• Yamamoto, Masashi
• Fukui, Koji

Titel

Drug-induced Interstitial Nephritis in a Patient with Ulcerative Colitis Treated with 5-Aminosalicylic Acid: A Case Report

Ist Teil von

• Internal Medicine, 2023, pp.2366-23

Ort / Verlag

The Japanese Society of Internal Medicine

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• This report describes the case of a 76-year-old man with ulcerative colitis who developed interstitial nephritis after starting 5-aminosalicylic acid (5-ASA) therapy. The patient experienced an initial improvement in symptoms, but developed fatigue, anorexia, and severe renal dysfunction 2.5 months later. Renal biopsy confirmed drug-induced interstitial nephritis, and conservative treatment with fluid replacement and the discontinuation of 5-ASA improved the patient's condition. Clinicians should monitor patients receiving 5-ASA therapy for potential adverse effects, particularly renal injury, and promptly investigate symptoms of renal dysfunction. Early recognition and discontinuation of the offending agent may prevent further damage and improve patient outcomes.