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Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse
Ist Teil von
Expert opinion on drug metabolism & toxicology, 2009-07, Vol.5 (7), p.731-744
Ort / Verlag
England: Informa UK Ltd
Erscheinungsjahr
2009
Link zum Volltext
Quelle
Taylor & Francis
Beschreibungen/Notizen
Background: Testosterone replacement therapy in hypogonadal men has been used for > 60 years. The use of testosterone substitution is continuously growing and is given to aging men to improve the quality of life. Because testosterone use is associated with muscle strength enhancing effects, it has become a popular drug to abuse. Doping with anabolic steroids, such as testosterone, is a severe challenge to the vision, moral and ethics in sports and has also become a significant and increasing problem in society. Objective: The primary aim of this review is to summarize and discuss the contribution of genetic components to inter-individual variation in androgen disposition. Conclusion: Genetic variation has a large impact on androgen disposition. This variation is of the utmost importance for the interpretation of doping test results and may modulate the effects of testosterone replacement therapy and testosterone doping.