Details

Autor(en) / Beteiligte

• El-Domiaty, Maher M.
• Wink, Michael
• Aal, Mahmoud M. Abdel
• Abou-Hashem, Maged M.
• Abd-Alla, Rehab H.

Titel

Antihepatotoxic Activity and Chemical Constituents of Buddleja asiatica Lour

Ist Teil von

• Zeitschrift für Naturforschung C. A journal of biosciences, 2009-01, Vol.64 (1), p.11-19

Ort / Verlag

Germany: Verlag der Zeitschrift für Naturforschung

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A new natural compound, named 6-O-(3’’,4’’-dimethoxycinnamoyl) catalpol, was isolated from the defatted alcoholic extract of the flowering parts of Buddleja asiatica Lour. (family Scrophulariaceae). Other separated known compounds included steroids (β-sitosterol, stigmasterol, stigmasterol-O-glucoside, β-sitosterol-O-glucoside), iridoid glucosides (methyl catalpol, catalpol, aucubin), phenylpropanoids (isoacteoside and acteoside), a triterpene saponin (mimengoside A), flavonoids (diosmin and linarin) in addition to the free sugars mannitol and sucrose. The structures of the isolated compounds were established by H and C NMR and mass spectrometry. Furthermore, the polar fraction of the flowering parts and the roots showed substantial antihepatotoxic activity comparable to that of the lignan silymarin.