Details

Autor(en) / Beteiligte

• Ergin Tuncay, Merve
• Gemcioglu, Emin
• Kayaaslan, Bircan
• Ates, Ihsan
• Guner, Rahmet
• Eser, Fatma
• Hasanoglu, Imran
• Kaya Kalem, Ayse
• Aypak, Adalet
• Agac, Zubeyr Said
• Gokbulut Bektas, Serife
• Mungan, Ibrahim
• Akdag, Ahmet Gokhan
• Izdes, Seval
• Neselioglu, Salim
• Erel, Ozcan

Titel

A notable key for estimating the severity of COVID-19: 25-hydroxyvitamin D status

Ist Teil von

• Turkish Journal of Biochemistry, 2021-01, Vol.46 (2), p.167-172

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Background Vitamin D is recognized to be an immune regulator. Also, it is known to have antiviral effects by several mechanisms, including reducing inflammatory cytokines. Objectives To examine the 25-hydroxyvitamin D (25(OH)D) status for assessing the severity of COVID-19. Methods This study consisted of 596 patients confirmed as SARS-CoV-2 infection and 59 healthy individuals. The cases separated into non-severe group, severe survival, and severe non-survival group. 25(OH)D and other laboratory parameters were evaluated retrospectively. Results In all COVID-19 groups 25(OH)D levels were low compared to controls (p<0.05). 25(OH)D concentrations were lowest in patients in severe non-survival groups than those in other SARS-CoV-2 infection groups (p<0.05). Multivariate regression analysis exhibited that decreasing 25(OH)D was associated with an increased likelihood of non-severe, severe survival and severe non-survival disease. There were significant associations between 25(OH)D and certain inflammatory and hemostatic parameters (p<0.05, for all). Conclusions 25(OH)D deficiency was observed among patients with COVID-19. Declined steadily 25(OH)D levels make a huge contribution to the scale of the progression of the disease. Correlations support that 25(OH)D may be a substantial tool for utilizing the severity of the disease and estimating the survival. Also, supplementation of 25(OH)D might slow down the course of the COVID-19.