Details

Autor(en) / Beteiligte

• Elsheikha, Hany
• Castro, Pablo David Jimenez

Titel

Anthelmintics: targets, mechanisms and resistance

Ist Teil von

• Companion animal (London, England), 2015-08, Vol.20 (8), p.436-441

Erscheinungsjahr

2015

Beschreibungen/Notizen

• The past few decades have witnessed a clear shift in the management of worm infections, with more emphasis on chemotherapeutic drugs. Anthelmintics have been effective in limiting the spread of helminth infections, with consequent improvement in the welfare of pets and the productivity of domestic animals. Hence, the use of anthelmintics has been one of the greatest achievements of the parasitology discipline. However, infections with parasites remain both common and serious. Not only has there been evidence of incidence of parasites that are resistant to the action of anthelmintics, but the spectrum of infection also seems to be changing, with a growing number of emerging and re-emerging infections, suggesting a shift in the landscape of the interactions between animal host and parasites. Therefore, the role for integrated parasite control programmes has grown, and will continue to grow, as rates of anthelmintics resistance are likely to rise. Management of worm infections should rely on the sensible application of anthelmintics to alleviate disease and maintain welfare, and sound hygienic measures to reduce the transmission of parasites. In this article, we summarize the most common anthelmintic drugs for dogs and cats, highlighting their modes of action, the potential for development of drug resistance (DR), and ways to tackle the DR challenge.