Details

Autor(en) / Beteiligte

• Lopez-Delgado, Juan Carlos
• Mendiluce, Rafael Mañez
• Pinol, Teresa Serrano
• Fernández, Xose Pérez
• Sanchez, Laura
• Vicente, Rosa Granada

Titel

Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature

Ist Teil von

• Annals of transplantation, 2012-01, Vol.17 (1), p.122-127

Ort / Verlag

United States

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Acute liver failure (ALF) due to antiretroviral treatment is a rare but a fatal complication in HIV-infected patients. Non-nucleoside retroviral transcriptase inhibitors are known to cause hepatotoxicity and exceptionally acute hepatic failure. We report a case of nevirapine-induced acute liver failure successfully managed with orthotopic liver transplantation (OLT). Antiretroviral therapy including raltegravir, zidovudine and abacavir was reintroduced 6 days after transplantation. No interaction with immunosuppressive agents was observed and the patient had a complete recovery. Urgent OLT should be considered in HIV patients with nevirapine-induced ALF because of the poor outcome despite intensive supportive conservative treatment. Concomitant use of highly active antiretroviral therapy (HAART) and immunosuppression could be feasible if treatment is performed cautiously.