Details

Autor(en) / Beteiligte

• SHIMIZU, Hiroshi
• KARAI, Nobuyuki
• HIROSE, Akira
• TATSUNO, Tohru
• TANAKA, Hiroyasu
• KUMASAKA, Yoshino
• NAKAMURA, Mitsutaka

Titel

Interaction of SM-3997 with Serotonin Receptors in Rat Brain

Ist Teil von

• The Japanese Journal of Pharmacology, 1988, Vol.46(3), pp.311-314

Ort / Verlag

The Japanese Pharmacological Society

Erscheinungsjahr

1988

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT1A receptors but not the BZ-GABA receptor complex.