Details

Autor(en) / Beteiligte

• Sangeetha, T.
• Quine, S. Darlin

Titel

Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury

Ist Teil von

• Journal of pharmacy and pharmacology, 2006-05, Vol.58 (5), p.617-623

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2006

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• The present study was designed to evaluate the preventive effect of S‐allyl cysteine sulfoxide (SACS) in isoproterenol (ISO)‐induced myocardial ischaemia in male Wistar rats. Rats were pretreated with SACS (40 and 80 mg kg−1 body‐weight) for 5 weeks. After the treatment period, ISO (150 mg kg−1 body‐weight) was administered subcutaneously to rats at intervals of 24 h for 2 days. The activities of creatine kinase, creatine kinase‐MB, lactate dehydrogenase, aspartate transaminase and alanine transferase were significantly increased in serum and significantly decreased in the hearts of ISO‐treated rats. Pretreatment with SACS decreased the activities of these enzymes significantly in serum and significantly increased the activities in heart in ISO‐treated rats. The levels of cholesterol, triglycerides and free fatty acids increased in serum and heart, while the levels of phospholipids increased in serum and decreased in heart in ISO‐treated rats. SACS pretreatment showed a significant effect on the lipids studied. The activity of 3‐hydroxy 3‐methyl glutaryl coenzyme A (HMG CoA) reductase was significantly increased and the activity of lecithin cholesterol acyl transferase (LCAT) was significantly reduced in ISO‐induced rats. Oral pretreatment with SACS significantly decreased the activity of HMG CoA reductase and significantly increased the activity of LCAT in ISO‐induced rats. The levels of plasma thiobarbituric acid reactive substances and hydroperoxides were increased in ISO‐treated rats. Pretreatment with SACS significantly decreased the levels of lipidperoxides in ISO‐treated rats. The effect at a dose of 80 mg kg−1 body‐weight was more effective than at a dose of 40 mg kg−1 body‐weight and brought back all the biochemical parameters to near normal levels. Thus our study shows that SACS has a lipid‐lowering effect in ISO‐induced rats. Our study may have clinical relevance.