Details

Autor(en) / Beteiligte

• Smith, F P
• Stablein, D
• Korsmeyer, S
• Neefe, J
• Chun, B K
• Woolley, P V
• Schein, P S

Titel

Combination chemotherapy for locally advanced pancreatic cancer: equivalence to external beam irradiation and implication for future management

Ist Teil von

• Journal of clinical oncology, 1983-07, Vol.1 (7), p.413-415

Ort / Verlag

United States: American Society of Clinical Oncology

Erscheinungsjahr

1983

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Chemotherapy with 5-fluorouracil, doxorubicin, and mitomycin-C was administered to 17 patients with locally advanced pancreatic cancer. The median survival for these patients was 8 months. With a multiaxial retrospective analysis, the overall survival of this study group appears to be least equivalent to that reported with 6,000 photon rad alone or of neutrons, and compares favorably to that achieved with combined 6,000 photo rad plus 5-fluorouracil. Of 15 relapses, only 4 had presented with evidence of disseminated disease. Based upon this analysis we recommend additional studies of combination chemotherapy with radiation therapy in future prospective randomized trials.